The labia majora are two sagittal oriented skin folds containing adipose tissue that merge anteriorly and posteriorly. The labia majora are located inferior to the mons pubis.

The joining site of both labia in the front is called the anterior commissure, while posteriorly - posterior commissure.

Between both labia majora is a space called the pudendal cleft (also called the rima pudendi).

The skin on the outer side is pigmented, hairy, and contains a high concentration of sebaceous and sweat glands, while the inner part resembles a mucous membrane and does not contain hair.

In the anterior part of the labia majora are located fibers of the round ligament of the uterus as they go through the inguinal canal and reach the labia majora, and terminate in the mons pubis.